Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009384 | 0.81 | MAP2K4 (0.46) | CYP3A4NPC1RAB9AKDM4ECA12 | |
| SCHEMBL4807576 | 0.77 | ALDH1A1 (0.43) | NPC1RAB9AALOX5KDM4ECA12 | |
| SCHEMBL4008802 | 0.77 | HSD17B10 (0.45) | CYP3A4NPC1RAB9AALOX5KDM4E | |
| SCHEMBL5887276 | 0.77 | MAPT (0.48) | CYP3A4NPC1RAB9AKDM4ELMNA | |
| SCHEMBL2125610 | 0.77 | MAP2K4 (0.49) | KDM4ECA12CA2CA9LMNA | |
| SCHEMBL11369493 | 0.77 | GAPDH (0.51) | CYP3A4NPC1RAB9AKDM4ELMNA | |
| SCHEMBL3137032 | 0.77 | PTGS2 (0.47) | NPC1RAB9AKDM4ECA12CA2 | |
| SCHEMBL7015047 | 0.76 | ALDH1A1 (0.49) | CYP3A4NPC1RAB9AKDM4ETP53 | |
| SCHEMBL5887412 | 0.75 | PTGS2 (0.56) | CA12CA2CA9PTGS2PTPRC | |
| SCHEMBL5886845 | 0.74 | ALDH1A1 (0.43) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903349-B1 | CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | disclosed |
| EP-0903349-A2 | CCR-3 receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-24 | — | — | EP | disclosed |