Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 3/20 | 0.35 |
| ▸ | MDH2 | P40926 | 3/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574329 | 1.00 | LMNA (0.39) | LMNAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL574027 | 0.86 | MAPT (0.40) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL574028 | 0.86 | MAPT (0.40) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL11204853 | 0.81 | ADORA2A (0.41) | ALDH1A1MEN1KMT2ACYP1A2TSHR | |
| SCHEMBL10224339 | 0.79 | SMN1; SMN2 (0.38) | LMNAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL572903 | 0.78 | KDM4E (0.38) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL572902 | 0.78 | KDM4E (0.38) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL573292 | 0.75 | VCAM1 (0.47) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL573293 | 0.75 | VCAM1 (0.47) | LMNAALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL11542934 | 0.73 | SMN1; SMN2 (0.56) | LMNAALDH1A1KMT2ACYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |