Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572902 | 1.00 | KDM4E (0.38) | KDM4EALDH1A1GAAHPGDPKM | |
| SCHEMBL10224339 | 0.86 | SMN1; SMN2 (0.38) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL573292 | 0.82 | VCAM1 (0.47) | KDM4EALDH1A1HPGDPKMSMN1; SMN2 | |
| SCHEMBL573293 | 0.82 | VCAM1 (0.47) | KDM4EALDH1A1HPGDPKMSMN1; SMN2 | |
| SCHEMBL11512665 | 0.82 | ALDH1A1 (0.39) | KDM4EALDH1A1GAAHPGDPKM | |
| SCHEMBL574219 | 0.81 | HPGD (0.45) | KDM4EALDH1A1GAAHPGDPKM | |
| SCHEMBL574218 | 0.81 | HPGD (0.45) | KDM4EALDH1A1GAAHPGDPKM | |
| SCHEMBL11542934 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1GAAHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL10996371 | 0.80 | GAA (0.43) | KDM4EALDH1A1GAAHPGDPKM | |
| SCHEMBL10996368 | 0.80 | GAA (0.43) | KDM4EALDH1A1GAAHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |