Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
| ▸ | CPT1A | P50416 | 5/20 | 0.37 |
| ▸ | CPT2 | P23786 | 4/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741071 | 0.83 | USP30 (0.40) | GRM5GCKUSP30GPR119UCHL1 | |
| SCHEMBL5741411 | 0.74 | IKBKB (0.50) | GRM5USP30IKBKBPOLBMEN1 | |
| SCHEMBL28814072 | 0.72 | PRMT5 (0.55) | GRM5CPT1AUSP30GPR119PRMT5 | |
| SCHEMBL29491244 | 0.72 | PRMT5 (0.55) | GRM5CPT1AUSP30GPR119PRMT5 | |
| SCHEMBL5744548 | 0.71 | IKBKB (0.46) | GRM5USP30IKBKBPOLBADORA2A | |
| SCHEMBL2307181 | 0.71 | CPT1A (0.67) | GRM5CPT1ACPT2GPR119CPT1B | |
| SCHEMBL2307483 | 0.71 | CPT1A (0.67) | CPT1ACPT2CPT1BALDH1A1LMNA | |
| SCHEMBL2307492 | 0.71 | CPT1A (0.67) | CPT1ACPT2CPT1BALDH1A1LMNA | |
| SCHEMBL2307175 | 0.71 | CPT1A (0.67) | GRM5CPT1ACPT2GPR119CPT1B | |
| SCHEMBL5741008 | 0.70 | USP30 (0.44) | GRM5USP30IKBKBGPR119PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |