Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741008 | 0.86 | USP30 (0.44) | USP30GRM5GPR119MEN1ALDH1A1 | |
| SCHEMBL5743459 | 0.83 | GRM5 (0.39) | USP30POLBGCKADORA2AADORA1 | |
| SCHEMBL22039535 | 0.74 | HSD11B1 (0.54) | POLBGPR119TSHRMEN1ALDH1A1 | |
| SCHEMBL29785710 | 0.74 | HSD11B1 (0.54) | POLBGPR119TSHRMEN1ALDH1A1 | |
| SCHEMBL5741045 | 0.74 | ALOX5AP (0.42) | GPR119MEN1ALDH1A1KMT2A | |
| SCHEMBL29747542 | 0.73 | GPR119 (0.46) | USP30POLBGCKGPR119TSHR | |
| SCHEMBL3859454 | 0.72 | SCD5 (0.48) | USP30POLBGRM5GPR119TSHR | |
| SCHEMBL3852498 | 0.72 | SCD5 (0.48) | USP30POLBGRM5GPR119TSHR | |
| SCHEMBL29491244 | 0.71 | PRMT5 (0.55) | USP30POLBGRM5GPR119TSHR | |
| SCHEMBL28814072 | 0.71 | PRMT5 (0.55) | USP30POLBGRM5GPR119TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |