Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741411 | 0.97 | IKBKB (0.50) | IKBKBKDM4EALDH1A1HPGDGLA | |
| SCHEMBL5741483 | 0.83 | IKBKB (0.63) | IKBKBCHUK | |
| SCHEMBL5743459 | 0.71 | GRM5 (0.39) | IKBKBKDM4EALDH1A1MEN1TSHR | |
| SCHEMBL1895705 | 0.70 | ADORA1 (0.71) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL5741071 | 0.69 | USP30 (0.40) | KDM4EALDH1A1HCRTR1MEN1TSHR | |
| SCHEMBL8276253 | 0.68 | RAB9A (0.64) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL4786519 | 0.68 | RAB9A (0.64) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL5743706 | 0.67 | IKBKB (0.57) | IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL4958803 | 0.67 | RAB9A (0.62) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4787881 | 0.67 | RAB9A (0.62) | KDM4EALDH1A1HPGDGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |