Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PLAU | P00749 | 4/20 | 0.55 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | F10 | P00742 | 2/20 | 0.55 |
| ▸ | PLAT | P00750 | 2/20 | 0.55 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314179 | 0.83 | C1S (0.45) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL1175614 | 0.78 | HPGD (0.69) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL3367963 | 0.78 | ALOX15 (0.57) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL23850208 | 0.77 | ALDH1A1 (0.50) | HPGDCYP1A2PLAUF2F10 | |
| SCHEMBL16079251 | 0.77 | DGAT1 (0.50) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL21884653 | 0.76 | PLAU (0.61) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL6154796 | 0.74 | ALOX15 (0.69) | ALOX15HPGDCES2GALR3CYP1A2 | |
| SCHEMBL8267256 | 0.74 | PLAU (0.55) | ALOX15HPGDPLAUF2F10 | |
| SCHEMBL5742419 | 0.74 | CA1 (0.55) | ALOX15HPGDCYP2C9CASP1CYP2C19 | |
| SCHEMBL14816685 | 0.74 | C1S (0.45) | ALOX15HPGDCES2GALR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153023-A1 | BENZOXAZOLE KINASE INHIBITORS AND METHODS OF USE | Intellikine, LLC (US) | 2017-04-12 | — | — | EP | disclosed |
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |