Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5743585 | 0.99 | DYRK1A (0.56) | DYRK1AKDM4EHSD17B10HTTCYP11B2 | |
| SCHEMBL5747051 | 0.82 | ALDH1A1 (0.51) | DYRK1AKDM4EHSD17B10HTTALDH1A1 | |
| SCHEMBL6381176 | 0.74 | ADORA1 (0.50) | KDM4EHTTALDH1A1ADORA1ADORA2A | |
| SCHEMBL14809869 | 0.72 | ADORA2A (0.58) | DYRK1AKDM4EHSD17B10HTTCYP11B2 | |
| SCHEMBL1606265 | 0.71 | CYP11B2 (0.61) | DYRK1ACYP11B2CYP11B1ADORA1ADORA2A | |
| SCHEMBL9268713 | 0.71 | DYRK1A (0.50) | DYRK1AKDM4EHSD17B10HTTCYP11B2 | |
| SCHEMBL9273581 | 0.71 | DYRK1A (0.50) | DYRK1AKDM4EHSD17B10HTTCYP11B2 | |
| SCHEMBL29994370 | 0.70 | CYP11B2 (0.64) | DYRK1ACYP11B2CYP11B1DHODHPDE10A | |
| SCHEMBL1604750 | 0.70 | CYP11B2 (0.64) | DYRK1ACYP11B2CYP11B1DHODHPDE10A | |
| SCHEMBL6383208 | 0.69 | LMNA (0.43) | TSHRALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842923-B1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU CO LTD (JP) | 2006-03-01 | — | — | EP | disclosed |
| US-6172102-B1 | POLLAKIURIA OR URINARY INCONTINENCE | NIPPON SHINYAKU CO., LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| US-5998459-A | INCOTINENCE THERAPY | NIPPON SHINYAKU CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0842923-A1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |