Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745544 | 0.82 | CHRNA7 (0.60) | — | |
| SCHEMBL17315098 | 0.70 | CYP3A4 (0.64) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL3990221 | 0.70 | CYP3A4 (0.55) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL4757507 | 0.70 | CYP3A4 (0.55) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL5647102 | 0.69 | ALDH1A1 (0.62) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL27834151 | 0.68 | CYP3A4 (0.53) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL4661827 | 0.68 | CYP3A4 (0.53) | HTR2AHTR2CHTR2BHTTCYP3A4 | |
| SCHEMBL2762690 | 0.67 | CHRNA3 (0.45) | HTR2CHTR2BCYP1A2 | |
| SCHEMBL5649609 | 0.67 | CYP1A2 (0.57) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2763504 | 0.67 | KMT2A (0.48) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231212-B1 | Pharmaceutical compositions for the treatment of disorders of the CNS and other disorders | PFIZER PROD INC (US) | 2006-12-20 | — | — | EP | claimed |