Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.68 |
| ▸ | PGR | P06401 | 12/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742193 | 0.91 | NR3C1 (0.69) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL5744672 | 0.90 | NR3C1 (0.67) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL4619251 | 0.90 | NR3C1 (0.72) | NR3C1PGRNR3C2AR | |
| SCHEMBL5742841 | 0.89 | NR3C1 (0.66) | NR3C1PGRNR3C2ARRAB9A | |
| SCHEMBL6326838 | 0.88 | NR3C1 (0.55) | NR3C1PGRNR3C2AR | |
| SCHEMBL4137958 | 0.83 | NR3C1 (0.60) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL4616683 | 0.82 | NR3C1 (0.58) | NR3C1PGRNR3C2AR | |
| SCHEMBL293071 | 0.81 | PGR (1.00) | NR3C1PGRNR3C2 | |
| SCHEMBL292196 | 0.81 | NR3C1 (1.00) | NR3C1PGRNR3C2AR | |
| SCHEMBL5744371 | 0.81 | NR3C1 (0.68) | NR3C1PGRNR3C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467982-B1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL FORMULATIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2006-11-22 | — | — | EP | claimed |
| US-7189758-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189758-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-6960581-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-11-01 | — | — | US | disclosed |