Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.67 |
| ▸ | PGR | P06401 | 13/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742193 | 0.91 | NR3C1 (0.69) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL5744285 | 0.90 | NR3C1 (0.68) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL4619251 | 0.89 | NR3C1 (0.72) | NR3C1PGRNR3C2AR | |
| SCHEMBL5740864 | 0.88 | NR3C1 (0.54) | NR3C1PGRNR3C2AR | |
| SCHEMBL5742841 | 0.88 | NR3C1 (0.66) | NR3C1PGRNR3C2ARRAB9A | |
| SCHEMBL4137958 | 0.82 | NR3C1 (0.60) | NR3C1PGRNR3C2ARNPC1 | |
| SCHEMBL4616683 | 0.81 | NR3C1 (0.58) | NR3C1PGRNR3C2AR | |
| SCHEMBL293071 | 0.81 | PGR (1.00) | NR3C1PGRNR3C2 | |
| SCHEMBL5742909 | 0.80 | NR3C1 (0.66) | NR3C1PGRNR3C2AR | |
| SCHEMBL292715 | 0.80 | PGR (0.98) | NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467982-B1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL FORMULATIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2006-11-22 | — | — | EP | claimed |
| US-7189758-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189758-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-6960581-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-11-01 | — | — | US | disclosed |