Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468172 | 0.89 | KMT2A (0.48) | KMT2AMEN1L3MBTL1ALDH1A1ALOX5 | |
| SCHEMBL2474108 | 0.84 | BCL2L1 (0.55) | KMT2AMEN1CA2MMP2CA1 | |
| SCHEMBL6025519 | 0.75 | KMT2A (0.49) | KMT2AMEN1L3MBTL1ALOX5CA2 | |
| SCHEMBL6525578 | 0.74 | ALOX5 (0.51) | KMT2AMEN1L3MBTL1ALDH1A1ALOX5 | |
| SCHEMBL6026285 | 0.73 | KMT2A (0.47) | KMT2AMEN1L3MBTL1ALOX5CA2 | |
| SCHEMBL6531285 | 0.73 | KMT2A (0.46) | KMT2AMEN1L3MBTL1ALOX5CA2 | |
| SCHEMBL6470751 | 0.72 | ALDH1A1 (0.40) | ALDH1A1PGRGAA | |
| SCHEMBL6468938 | 0.71 | KMT2A (0.58) | KMT2AMEN1L3MBTL1ALDH1A1ALOX5 | |
| SCHEMBL6530526 | 0.70 | KMT2A (0.51) | KMT2AMEN1L3MBTL1ALDH1A1ALOX5 | |
| SCHEMBL2950676 | 0.70 | BCL2L1 (0.73) | KMT2AALDH1A1GAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |