Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 12/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PTPRF | P10586 | 1/20 | 0.30 |
| ▸ | PTPRA | P18433 | 1/20 | 0.30 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.30 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743846 | 0.77 | TAS2R14 (0.36) | MTNR1AMTNR1BPTPN1KEAP1 | |
| SCHEMBL5744959 | 0.73 | MTNR1A (0.36) | MTNR1AMTNR1BPTPN1MAPTPTPRF | |
| SCHEMBL5740580 | 0.73 | PTPN1 (0.36) | MTNR1AMTNR1BPTPN1KEAP1 | |
| SCHEMBL4267879 | 0.71 | PTPN1 (0.34) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL5742273 | 0.69 | PTPN1 (0.39) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL4800192 | 0.68 | PTPN1 (0.38) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL4806715 | 0.68 | PTPN1 (0.38) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL4264214 | 0.67 | MTNR1A (0.38) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL4261637 | 0.67 | PTPN1 (0.38) | MTNR1AMTNR1BPTPN1PTPRFPTPRA | |
| SCHEMBL4260725 | 0.66 | ALDH1A1 (0.39) | MTNR1AMTNR1BPTPN1PTPRFPTPRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006525365-A | — | — | 2006-11-09 | — | — | JP | claimed |
| EP-1620422-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004099170-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | claimed |