Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745160 | 0.94 | HTR1B (0.46) | SLC6A4SLC6A2HRH1HTR1BHTR1D | |
| SCHEMBL5747032 | 0.83 | HTR1B (0.49) | HTR1BALDH1A1KCNA3TSHRGAA | |
| SCHEMBL5749144 | 0.81 | HTR1B (0.48) | HTR1BKDM4EPOLBKCNA3HPGD | |
| SCHEMBL5745853 | 0.81 | HTR1B (0.53) | SLC6A4HRH1HTR1BALDH1A1KDM4E | |
| SCHEMBL5750596 | 0.81 | HRH1 (0.53) | SLC6A4HRH1HTR1BHTR1DALDH1A1 | |
| SCHEMBL5748300 | 0.81 | HTR1B (0.56) | HTR1BHTR1DALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5746113 | 0.80 | MAPT (0.49) | SLC6A4SLC6A2HRH1HTR1BHTR1D | |
| SCHEMBL5747008 | 0.80 | HTR1B (0.56) | HTR1BHTR1DALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5747450 | 0.79 | HTR1B (0.52) | SLC6A4HRH1HTR1BHTR1DALDH1A1 | |
| SCHEMBL5748004 | 0.79 | CYP2D6 (0.50) | ALDH1A1HRH3SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |