Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748300 | 0.98 | HTR1B (0.56) | HTR1BADRB2KDM4EALDH1A1HPGD | |
| SCHEMBL5747008 | 0.89 | HTR1B (0.56) | HTR1BADRB2KDM4EALDH1A1HPGD | |
| SCHEMBL5750596 | 0.88 | HRH1 (0.53) | HTR1BADRB2KDM4EALDH1A1HPGD | |
| SCHEMBL5746733 | 0.87 | HTR1B (0.51) | HTR1BADRB2HPGDKCNA3MCL1 | |
| SCHEMBL5747450 | 0.86 | HTR1B (0.52) | HTR1BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5749009 | 0.85 | HTR1B (0.56) | HTR1BADRB2KDM4EALDH1A1HPGD | |
| SCHEMBL5747032 | 0.83 | HTR1B (0.49) | HTR1BALDH1A1KCNA3TSHRMCL1 | |
| SCHEMBL5749144 | 0.81 | HTR1B (0.48) | HTR1BKDM4EHPGDMAPK1KCNA3 | |
| SCHEMBL5745052 | 0.81 | SLC6A4 (0.46) | HTR1BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5745160 | 0.80 | HTR1B (0.46) | HTR1BKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |