Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 2/20 | 0.37 |
| ▸ | ATP4B | P51164 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748287 | 0.90 | SLC6A2 (0.42) | RAB9ASLC6A2HTR1BDRD2DRD3 | |
| SCHEMBL5770644 | 0.89 | SLC6A4 (0.48) | RAB9ASLC6A2HTR1BDRD2DRD3 | |
| SCHEMBL5770349 | 0.82 | HTR1B (0.49) | SLC6A2HTR1BDRD2DRD3SLC6A4 | |
| SCHEMBL28824473 | 0.79 | GPR3 (0.43) | SLC6A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5746664 | 0.79 | SLC6A4 (0.43) | RAB9ASLC6A2HTR1BDRD2DRD3 | |
| SCHEMBL5747600 | 0.75 | HTR1B (0.47) | HTR1BDRD2DRD3KDM4E | |
| SCHEMBL5746059 | 0.75 | HTR1B (0.45) | SLC6A2HTR1BDRD3SLC6A4HRH1 | |
| SCHEMBL5776857 | 0.73 | HTR1B (0.45) | HTR1BDRD2DRD3KDM4ETSHR | |
| SCHEMBL5746680 | 0.73 | HTR1B (0.44) | HTR1BKDM4EALDH1A1 | |
| SCHEMBL5748317 | 0.72 | HRH1 (0.49) | HTR1BSLC6A4HRH1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |