Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745923 | 0.90 | HTR1B (0.49) | HTR1BDRD2DRD4DRD3GRIN1 | |
| SCHEMBL5776857 | 0.89 | HTR1B (0.45) | HTR1BDRD2DRD4DRD3GRIN1 | |
| SCHEMBL5748317 | 0.82 | HRH1 (0.49) | HTR1BKMT2ASIGMAR1KDM4E | |
| SCHEMBL28824473 | 0.79 | GPR3 (0.43) | KMT2APGRRORARORCRORB | |
| SCHEMBL5745721 | 0.79 | HTR1B (0.47) | HTR1BKMT2AKDM4E | |
| SCHEMBL23469588 | 0.76 | PGR (0.53) | GRIN1GRIN2AGRIN2BSIGMAR1PGR | |
| SCHEMBL5745083 | 0.75 | RAB9A (0.44) | HTR1BDRD2DRD3KDM4E | |
| SCHEMBL5747322 | 0.75 | HTR1B (0.45) | HTR1BKMT2AKDM4E | |
| SCHEMBL5770644 | 0.73 | SLC6A4 (0.48) | HTR1BDRD2DRD3SIGMAR1 | |
| SCHEMBL5746680 | 0.73 | HTR1B (0.44) | HTR1BGRIN1GRIN2AGRIN2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |