Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746664 | 0.90 | SLC6A4 (0.43) | SLC6A4HRH1SLC6A2ALDH1A1DRD3 | |
| SCHEMBL5745083 | 0.89 | RAB9A (0.44) | SLC6A4HRH1SLC6A2ALDH1A1DRD3 | |
| SCHEMBL5770349 | 0.83 | HTR1B (0.49) | SLC6A4HRH1SLC6A2ALDH1A1DRD3 | |
| SCHEMBL5748287 | 0.79 | SLC6A2 (0.42) | SLC6A2ALDH1A1DRD3DRD2TSHR | |
| SCHEMBL28824473 | 0.77 | GPR3 (0.43) | SLC6A2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL5746059 | 0.76 | HTR1B (0.45) | SLC6A4HRH1SLC6A2ALDH1A1DRD3 | |
| SCHEMBL4780222 | 0.75 | SLC6A4 (0.72) | SLC6A4HRH1SLC6A2TSHRNPY1R | |
| SCHEMBL5776857 | 0.74 | HTR1B (0.45) | DRD3DRD2TSHRHTR1BHTR2A | |
| SCHEMBL5746680 | 0.74 | HTR1B (0.44) | ALDH1A1HTR1BHTR2A | |
| SCHEMBL5748317 | 0.73 | HRH1 (0.49) | SLC6A4HRH1ALDH1A1TSHRHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |