Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748560 | 0.93 | HTR1B (0.60) | HTR1BADRB2HTTMAOAHTR7 | |
| SCHEMBL5749134 | 0.89 | MAOA (0.59) | HTR1BMAOABCHEACHE | |
| SCHEMBL5748254 | 0.86 | XDH (0.57) | HTR1BADRB2BCHEACHE | |
| SCHEMBL11843761 | 0.85 | XDH (0.51) | HTR1BSIGMAR1BCHEACHE | |
| SCHEMBL12967977 | 0.83 | CDC25A (0.52) | HTR1BADRB2MAOA | |
| SCHEMBL5745354 | 0.82 | MAOA (0.61) | HTR1BHTTMAOAHTR7BCHE | |
| SCHEMBL15473271 | 0.81 | CYP2A6 (0.59) | HTR1BADRB2MAOA | |
| SCHEMBL10431487 | 0.81 | ADRB2 (0.48) | HTR1BHRH1ADRB2HTTMAOA | |
| SCHEMBL5748059 | 0.81 | POLB (0.53) | HTR1BADRB2 | |
| SCHEMBL5747324 | 0.80 | HTR1B (0.58) | HTR1BHRH1ADRB2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |