Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742107 | 0.83 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9913291 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTPOLB | |
| SCHEMBL13036136 | 0.78 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2KDM4EHTTNPC1 | |
| SCHEMBL3696273 | 0.74 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2CYP1A2MAPK1MAPT | |
| SCHEMBL499877 | 0.71 | HTR2A (0.40) | ALDH1A1SMN1; SMN2CYP1A2MAPK1MAPT | |
| SCHEMBL13365583 | 0.71 | PKM (0.53) | ALDH1A1SMN1; SMN2MAPK1KDM4EMAPT | |
| SCHEMBL13993911 | 0.70 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2CYP1A2MAPK1KDM4E | |
| SCHEMBL13993907 | 0.70 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2CYP1A2MAPK1KDM4E | |
| SCHEMBL1220082 | 0.69 | GAA (0.43) | ALDH1A1SMN1; SMN2CYP1A2MAPK1KDM4E | |
| SCHEMBL5607969 | 0.69 | NAALAD2 (0.47) | ALDH1A1SMN1; SMN2CYP1A2NAALAD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446393-B1 | 2-AMINO-THIAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF INDUCIBLE NO-SYNTHASE | AVENTIS PHARMA SA (FR) | 2006-03-08 | — | — | EP | claimed |