Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544391 | 1.00 | NAALAD2 (0.47) | NAALAD2TSHRSMN1; SMN2KDM4CPKM | |
| SCHEMBL17206980 | 0.83 | PKM (0.36) | NAALAD2TSHRSMN1; SMN2PKMKDM4E | |
| SCHEMBL9595432 | 0.82 | POLB (0.39) | NAALAD2ALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL6206330 | 0.82 | NAALAD2 (0.35) | NAALAD2TSHRSMN1; SMN2KDM4CPKM | |
| SCHEMBL17961972 | 0.81 | NAALAD2 (0.47) | NAALAD2TSHRKDM4CPKMKDM4E | |
| SCHEMBL8995753 | 0.80 | FPR2 (0.50) | NAALAD2TSHRSMN1; SMN2ALDH1A1PIK3CD | |
| SCHEMBL8995750 | 0.80 | FPR2 (0.50) | NAALAD2TSHRSMN1; SMN2ALDH1A1PIK3CD | |
| SCHEMBL8995757 | 0.80 | FPR2 (0.50) | NAALAD2TSHRSMN1; SMN2ALDH1A1PIK3CD | |
| SCHEMBL6332111 | 0.80 | TSHR (0.46) | NAALAD2TSHRSMN1; SMN2KDM4CALDH1A1 | |
| SCHEMBL20468376 | 0.80 | PIK3CD (0.34) | NAALAD2TSHRSMN1; SMN2PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-A1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | Novartis AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | disclosed |