Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxyurea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyurea SCHEMBL21083113 | 0.88 | TSHR (0.62) | — | |
| Nitric Acid SCHEMBL1173278 | 0.84 | CA5A (0.53) | — | |
| Nitric Acid SCHEMBL1172643 | 0.81 | CA5A (0.50) | — | |
| Hydrazinecarboxamide SCHEMBL159341 | 0.81 | — | — | |
| Hydrazinecarboxamide SCHEMBL31298907 | 0.81 | TSHR (0.62) | — | |
| Nitric Acid SCHEMBL25282444 | 0.81 | CA5A (0.50) | — | |
| Urea SCHEMBL1122882 | 0.79 | CA5A (0.67) | — | |
| Urea SCHEMBL27597938 | 0.79 | CA5A (0.67) | — | |
| Urea SCHEMBL237222 | 0.79 | — | — | |
| Urea SCHEMBL10953403 | 0.79 | CA5A (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109069664-B | anti-CD 74 antibody conjugates, compositions comprising anti-CD 74 antibody conjugates, and methods of use of anti-CD 74 antibody conjugates | 苏特罗生物制药公司 | 2022-05-13 | — | — | CN | disclosed |
| EP-1622929-A2 | APO2L (TRAIL) RECEPTOR BINDING PEPTIDES AND USES THEREOF | Genentech, Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004101608-A2 | APO2L (TRAIL) RECEPTOR BINDING PEPTIDES AND USES THEREOF | GENENTECH, INC. (US) | 2004-11-25 | — | — | WO | disclosed |