Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745645 | 1.00 | CYP2D6 (0.42) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL8983515 | 0.77 | CYP2D6 (0.45) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL31669185 | 0.76 | OPRM1 (0.49) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL13400116 | 0.76 | CYP2D6 (0.44) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL15265126 | 0.74 | OPRM1 (0.48) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL2464534 | 0.74 | CYP2D6 (0.42) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL11886645 | 0.74 | KDM4E (0.49) | CYP2D6MC4RMEN1KMT2ACHRM2 | |
| SCHEMBL7161785 | 0.73 | SLC6A3 (0.43) | CYP2D6KCNA5CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL13553399 | 0.73 | KDM4E (0.51) | CYP2D6MC4RMEN1KMT2A | |
| SCHEMBL8983498 | 0.73 | ALDH1A1 (0.46) | CYP2D6CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1378753-B1 | A screening method and compounds for treating Friedreich Ataxia | SANTHERA PHARMACEUTICALS CH (CH) | 2006-05-31 | — | — | EP | claimed |
| US-20050222218-A1 | Screening method and compounds for treating friedreich ataxia | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-10-06 | — | — | US | claimed |
| EP-1378753-A1 | A screening method and compounds for treating Friedreich Ataxia | MYOCONTRACT AG (CH) | 2004-01-07 | — | — | EP | claimed |
| EP-1378753-B1 | A screening method and compounds for treating Friedreich Ataxia | SANTHERA PHARMACEUTICALS CH (CH) | 2006-05-31 | — | — | EP | disclosed |
| US-20050222218-A1 | Screening method and compounds for treating friedreich ataxia | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-10-06 | — | — | US | disclosed |
| WO-2004003565-A2 | A SCREENING METHOD AND COMPOUNDS FOR TREATING FRIEDREICH ATAXIA | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2004-01-08 | — | — | WO | disclosed |
| EP-1378753-A1 | A screening method and compounds for treating Friedreich Ataxia | MYOCONTRACT AG (CH) | 2004-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222218-A1 | Screening method and compounds for treating friedreich ataxia | GPX1, FECH, PRDX3 | CYP2D6 3836/4885KCNA5 3304/4885CYP3A4 4538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.