Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747826 | 0.91 | ADRB2 (0.59) | HTR1BKDM4EADRB2SMN1; SMN2HTT | |
| SCHEMBL5744105 | 0.87 | ADRB2 (0.55) | HTR1BKDM4EADRB2SMN1; SMN2HTT | |
| SCHEMBL5746575 | 0.85 | KDM4E (0.55) | HTR1BKDM4EADRB2SMN1; SMN2HTT | |
| SCHEMBL5746987 | 0.84 | HRH1 (0.51) | HTR1BKDM4EADRB2L3MBTL1ALDH1A1 | |
| SCHEMBL5747675 | 0.78 | HTR1B (0.46) | HTR1BKDM4ESMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5747194 | 0.77 | KDM4E (0.52) | HTR1BKDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5746581 | 0.73 | HRH3 (0.61) | KDM4ESMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL1795532 | 0.72 | DRD2 (0.43) | HTR1BKDM4EADRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL5748910 | 0.72 | HRH3 (0.63) | KDM4ESMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL5746264 | 0.72 | ALDH1A1 (0.54) | KDM4ESMN1; SMN2HTTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |