Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5747147 | 0.98 | ALDH1A1 (0.45) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| SCHEMBL8948339 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KCNA5LMNASMN1; SMN2POLB | |
| SCHEMBL5746915 | 0.84 | GAA (0.46) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| Bromide SCHEMBL5746911 | 0.82 | GAA (0.45) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| SCHEMBL7260309 | 0.78 | SMN1; SMN2 (0.55) | ALDH1A1KCNA5LMNASMN1; SMN2CES2 | |
| SCHEMBL3467316 | 0.75 | GAA (0.48) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| SCHEMBL13924228 | 0.75 | GAA (0.48) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| SCHEMBL27903781 | 0.75 | F7 (0.48) | ALDH1A1KCNA5LMNASMN1; SMN2MAPT | |
| SCHEMBL11148954 | 0.74 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2POLBTBXAS1 | |
| SCHEMBL9462640 | 0.74 | RAB9A (0.43) | KCNA5LMNASMN1; SMN2POLBTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664040-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| WO-2005026162-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 2272/4885KCNA5 4684/4885LMNA 881/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 2272/4885KCNA5 4684/4885LMNA 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.