Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4840274 | 0.90 | MAPK8 (0.40) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL4843076 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL5746650 | 0.85 | MAPK8 (0.45) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL5786235 | 0.85 | PABPC1 (0.40) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL3933284 | 0.80 | TSHR (0.42) | MAPK8MAPK9PLA2G2AKDM4EALDH1A1 | |
| SCHEMBL27605378 | 0.77 | MAPK14 (0.39) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL5235896 | 0.76 | KMT2A (0.48) | PLA2G2AATMKDM4EALDH1A1MAPT | |
| SCHEMBL5237509 | 0.74 | ALOX5 (0.41) | HIF1APLA2G2AATMKDM4EALDH1A1 | |
| SCHEMBL29834837 | 0.74 | MAPK8 (0.40) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL5787910 | 0.74 | TSHR (0.46) | KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492792-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO¬4,5-B|INDOLE-1-ACETAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | EP | disclosed |