Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747438 | 0.90 | MAPK8 (0.42) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL4843076 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL5786235 | 0.82 | PABPC1 (0.40) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL3933284 | 0.80 | TSHR (0.42) | MAPK8MAPK9MAPTHPGDTSHR | |
| SCHEMBL29834837 | 0.79 | MAPK8 (0.40) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL27605378 | 0.77 | MAPK14 (0.39) | MAPK8MAPK9TUBB4ATUBBTUBA3C | |
| SCHEMBL4841109 | 0.76 | ALOX15 (0.50) | MAPK8MAPK9HPGDTSHRALDH1A1 | |
| SCHEMBL17959424 | 0.76 | ALOX15 (0.47) | HPGDTSHRALDH1A1HSD17B10LMNA | |
| SCHEMBL5235896 | 0.76 | KMT2A (0.48) | MAPTHPGDTSHRATMALDH1A1 | |
| SCHEMBL5746650 | 0.75 | MAPK8 (0.45) | MAPK8MAPK9TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100543016-C | Intermediate compounds of 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives | SANOFI AVENTIS (FR) | 2009-09-23 | — | — | CN | disclosed |
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | US | disclosed |
| CN-100406459-C | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives, their preparation and use in therapy | SANOFI AVENTIS (FR) | 2008-07-30 | — | — | CN | disclosed |
| US-7405306-B2 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-07-29 | — | — | US | disclosed |
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7323467-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-01-29 | — | — | US | disclosed |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2007-09-20 | — | — | US | disclosed |
| US-7235554-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | SANOFI-AVENTIS (FR) | 2007-06-26 | — | — | US | disclosed |
| CN-1970538-A | Intermediate compounds of 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives | SANOFI AVENTIS (FR) | 2007-05-30 | — | — | CN | disclosed |
| CN-1656099-A | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives, their preparation and use in therapy | SANOFI AVENTIS (FR) | 2005-08-17 | — | — | CN | disclosed |
| US-20050124615-A1 | 3-heteroarly-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | SANOFI (FR) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | MAPK8 2034/4885MAPK9 4359/4885TUBB4A 1239/4885 |
| US-20050124615-A1 | 3-heteroarly-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | HRH4, IDO1, HTR4 | MAPK8 4380/4885MAPK9 4772/4885TUBB4A 721/4885 |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | MAPK8 2304/4885MAPK9 4137/4885TUBB4A 1171/4885 |
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | MAPK8 2034/4885MAPK9 4359/4885TUBB4A 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.