Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624108 | 0.90 | HPGD (0.46) | HPGDGPR119RECQLEPHX1STS | |
| SCHEMBL57106 | 0.84 | GPR119 (0.53) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL22532478 | 0.82 | HPGD (0.49) | HPGDGPR119RECQLEPHX1STS | |
| SCHEMBL1514778 | 0.81 | EPHX1 (0.52) | HPGDGPR119RECQLEPHX1STS | |
| SCHEMBL897784 | 0.81 | HPGD (0.48) | HPGDGPR119RECQLEPHX1STS | |
| SCHEMBL28720984 | 0.81 | STS (0.65) | GPR119STSSMN1; SMN2 | |
| SCHEMBL5313683 | 0.80 | HPGD (0.53) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL31496241 | 0.79 | GPR119 (0.61) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL4008565 | 0.79 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL29981135 | 0.79 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |
| CN-100354275-C | Pyrazolopyridine derivates | URIACH Y COMPAGNIA S A J (ES) | 2007-12-12 | — | — | CN | disclosed |
| CN-1753894-A | Pyrazolopyridine derivates | URIACH Y COMPAGNIA S A J (ES) | 2006-03-29 | — | — | CN | disclosed |