Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748978 | 0.96 | HTR1B (0.50) | HTR1BADRB2KDM4EPNMTDRD2 | |
| SCHEMBL5749104 | 0.90 | ADRB2 (0.57) | HTR1BADRB2KDM4EHTR1AADRA1D | |
| SCHEMBL5750385 | 0.86 | ADRB2 (0.52) | HTR1BADRB2KDM4EPNMTDRD2 | |
| SCHEMBL5745826 | 0.85 | HTR1B (0.53) | HTR1BADRB2KDM4EPNMTL3MBTL1 | |
| SCHEMBL5747936 | 0.83 | HRH1 (0.52) | HTR1BADRB2KDM4EPNMTL3MBTL1 | |
| Fluoride SCHEMBL28088547 | 0.83 | CYP1A2 (0.46) | HTR1BHTR1APNMTHTR1DNPC1 | |
| SCHEMBL28124467 | 0.82 | S1PR5 (0.48) | HTR1BHTR1APNMTHTR1D | |
| SCHEMBL28066660 | 0.79 | PNMT (0.49) | PNMTDRD2DRD4DRD3HTT | |
| Fluorene SCHEMBL9356605 | 0.77 | NPC1 (0.47) | HTR1BKDM4EPNMTSMN1; SMN2NPC1 | |
| SCHEMBL5749931 | 0.77 | PNMT (0.54) | HTR1BKDM4EPNMTDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |