Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749104 | 0.96 | ADRB2 (0.57) | ADRB2HTR1BKDM4EPNMTL3MBTL1 | |
| SCHEMBL5748978 | 0.91 | HTR1B (0.50) | ADRB2HTR1BKDM4EPNMTL3MBTL1 | |
| SCHEMBL5748191 | 0.86 | HTR1B (0.55) | ADRB2HTR1BKDM4EPNMTL3MBTL1 | |
| SCHEMBL5747936 | 0.86 | HRH1 (0.52) | ADRB2HTR1BKDM4EPNMTL3MBTL1 | |
| SCHEMBL5745826 | 0.85 | HTR1B (0.53) | ADRB2HTR1BKDM4EPNMTL3MBTL1 | |
| Fluoride SCHEMBL28088547 | 0.83 | CYP1A2 (0.46) | HTR1BPNMTNPC1RAB9A | |
| SCHEMBL28124467 | 0.82 | S1PR5 (0.48) | HTR1BPNMT | |
| SCHEMBL28066660 | 0.79 | PNMT (0.49) | PNMTL3MBTL1DRD2DRD4NPC1 | |
| SCHEMBL28088610 | 0.79 | PNMT (0.45) | HTR1BPNMTL3MBTL1DRD2DRD4 | |
| SCHEMBL5748197 | 0.79 | PNMT (0.53) | HTR1BKDM4EPNMTDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |