SCHEMBL5748468

SCHEMBL5748468

c1ccc2c(c1)oc1cccc(OCCN3CCCCC3)c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
TDP1 Q9NUW8 2/20 0.54
HRH3 Q9Y5N1 8/20 0.53
HTR2A P28223 2/20 0.53
HTR7 P34969 2/20 0.53
HTR6 P50406 2/20 0.53
HRH1 P35367 2/20 0.51
DRD2 P14416 1/20 0.51
DRD1 P21728 1/20 0.51
DRD4 P21917 1/20 0.51
DRD5 P21918 1/20 0.51
DRD3 P35462 1/20 0.51
MAOB P27338 5/20 0.51
XDH P47989 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
HSD17B10 Q99714 1/20 0.50
NMT2 O60551 1/20 0.49
NMT1 P30419 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5747870 0.99 TDP1 (0.55) TSHRTDP1HRH3HTR2AHTR7
SCHEMBL5749883 0.93 XDH (0.59) TDP1HRH3HTR2AHTR7HTR6
SCHEMBL5749264 0.92 TDP1 (0.59) TDP1HRH3HTR2AHTR7HTR6
SCHEMBL5748784 0.90 XDH (0.58) TSHRTDP1HRH3HTR2AHTR7
SCHEMBL5744863 0.89 TDP1 (0.56) TDP1HRH3HTR2AHTR7HTR6
SCHEMBL5748656 0.88 XDH (0.58) TSHRTDP1HRH3MAOBXDH
SCHEMBL5747713 0.86 XDH (0.55) TDP1HRH3MAOBXDHBCHE
SCHEMBL28675845 0.82 XDH (0.66) TDP1HRH3HTR2AHTR7HTR6
SCHEMBL14970486 0.79 HRH3 (0.81) TSHRTDP1HRH3HTR2AHTR7
Hydrochloric Acid SCHEMBL11882127 0.77 XDH (0.67) HRH3MAOBXDHBCHEACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1711463-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2006-10-18 EP claimed
WO-2005077899-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-08-25 WO claimed
EP-1711463-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2006-10-18 EP disclosed
WO-2005077899-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-08-25 WO disclosed