Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748833 | 1.00 | ADORA1 (0.42) | ADORA1AAK1P2RX7RBP4BACE1 | |
| SCHEMBL5747016 | 0.87 | P2RX7 (0.48) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5745574 | 0.87 | P2RX7 (0.48) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5743445 | 0.84 | MAPT (0.50) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5743443 | 0.84 | MAPT (0.50) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5745397 | 0.82 | SMN1; SMN2 (0.49) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5773095 | 0.82 | SMN1; SMN2 (0.49) | ADORA1P2RX7MAPTHTTMEN1 | |
| SCHEMBL5747677 | 0.81 | P2RX7 (0.48) | ADORA1P2RX7RBP4MEN1KMT2A | |
| SCHEMBL5747674 | 0.81 | P2RX7 (0.48) | ADORA1P2RX7RBP4MEN1KMT2A | |
| SCHEMBL5747701 | 0.81 | P2RX7 (0.48) | ADORA1P2RX7MAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487449-A4 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-08-23 | — | — | EP | claimed |
| US-7094895-B2 | Tyrosyl derivatives and their use as P2X7 receptor modulators | KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) | 2006-08-22 | — | — | US | claimed |
| EP-1487449-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | King Pharmaceuticals Research and Development Inc. (US) | 2004-12-22 | — | — | EP | claimed |
| US-20030181452-A1 | Tyrosyl derivatives and their use as P2X7 receptor modulators | CREDIT SUISSE AG | 2003-09-25 | — | — | US | claimed |
| WO-2003059353-A1 | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2003-07-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181452-A1 | Tyrosyl derivatives and their use as P2X7 receptor modulators | P2RX7, P2RX3, P2RX5 | ADORA1 47/4885AAK1 2084/4885P2RX7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.