Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745230 | 0.98 | HTR7 (0.52) | HTR7HRH3TDP1CYP2D6CYP2C19 | |
| SCHEMBL5746513 | 0.97 | HTR7 (0.48) | HTR7HRH3TDP1CYP2D6CYP2C19 | |
| SCHEMBL5746983 | 0.90 | HTR7 (0.47) | HTR7TDP1 | |
| SCHEMBL5746592 | 0.89 | HTR7 (0.48) | HTR7HRH3TDP1HTR2AHTR6 | |
| SCHEMBL5747302 | 0.87 | HTR7 (0.43) | HTR7TDP1ALDH1A1 | |
| SCHEMBL13305152 | 0.75 | SIGMAR1 (0.68) | HTR7CYP2D6CYP2C19ALDH1A1HTR2A | |
| SCHEMBL18010400 | 0.75 | DRD3 (0.62) | HTR7 | |
| SCHEMBL13305182 | 0.75 | TMEM97 (0.64) | HTR7 | |
| SCHEMBL5746680 | 0.74 | HTR1B (0.44) | TDP1CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18028059 | 0.73 | HTR7 (0.62) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |