Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.47 |
| ▸ | LTA4H | P09960 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746592 | 0.98 | HTR7 (0.48) | HTR7LTA4HTDP1TSHRPOLB | |
| SCHEMBL5747302 | 0.97 | HTR7 (0.43) | HTR7LTA4HTDP1TSHRPOLB | |
| SCHEMBL5748846 | 0.90 | HTR7 (0.51) | HTR7TDP1 | |
| SCHEMBL5745230 | 0.89 | HTR7 (0.52) | HTR7TDP1 | |
| SCHEMBL5746513 | 0.87 | HTR7 (0.48) | HTR7TDP1 | |
| SCHEMBL6657644 | 0.73 | MEN1 (0.45) | LTA4H | |
| SCHEMBL18028057 | 0.73 | POLB (0.58) | HTR7POLBRAD52 | |
| SCHEMBL11169002 | 0.73 | POLB (0.60) | LTA4HTDP1TSHRPOLB | |
| SCHEMBL7134330 | 0.72 | SRC (0.46) | LTA4H | |
| SCHEMBL28824473 | 0.72 | GPR3 (0.43) | TDP1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |