Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270136 | 0.87 | CNR1 (0.44) | MEN1KMT2ASMN1; SMN2MAPK1RIPK2 | |
| SCHEMBL7515835 | 0.87 | CLK4 (0.42) | MEN1KMT2AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL7826933 | 0.81 | IKBKB (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL6055066 | 0.79 | KDM4E (0.50) | MEN1KMT2AALDH1A1PIK3CDPIK3CA | |
| SCHEMBL5748864 | 0.76 | PIK3CD (0.58) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL3782102 | 0.76 | PIK3CD (0.57) | MEN1KMT2AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL2361495 | 0.76 | SMN1; SMN2 (0.40) | MEN1KMT2AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL8402143 | 0.73 | BTK (0.55) | BTK | |
| SCHEMBL2228840 | 0.70 | KDR (0.42) | MEN1KMT2AHPGDSMN1; SMN2PIK3CD | |
| SCHEMBL5088174 | 0.70 | PIK3CD (0.60) | MEN1KMT2AHPGDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482983-A4 | NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS | YISSUM RES DEV CO (IL) | 2006-07-12 | — | — | EP | claimed |
| EP-1482983-A2 | NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-12-08 | — | — | EP | claimed |
| WO-2003065971-A9 | NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS | YISSUM RES DEV CO (IL) | 2003-11-20 | — | — | WO | claimed |
| WO-2003065971-A2 | NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2003-08-14 | — | — | WO | claimed |
| EP-1638966-A2 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO ¬3,4-d| PYRIMIDINE AND PYRROLO ¬2,3-d| PYRIMIDINE AND USES THEREOF | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004106340-A2 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-d] PYRIMIDINE AND PYRROLO [2,3-d] PYRIMIDINE AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2004-12-09 | — | — | WO | disclosed |
| US-20020016976-A1 | Engineered protein kinases which can utilize modified nucleotide triphosphate substrates | PRINCETON UNIVERSITY | 2002-02-07 | — | — | US | disclosed |