Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748863 | 0.87 | MEN1 (0.42) | CLK4ALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL1270136 | 0.86 | CNR1 (0.44) | CLK4CDK5CDK8RAB9ANPC1 | |
| SCHEMBL7826933 | 0.85 | IKBKB (0.46) | CLK4CYP1A2ALPLMAPK10CDK2 | |
| SCHEMBL18040266 | 0.80 | DPP4 (0.49) | CLK4CDK5ALDH1A1KDM4ERAB9A | |
| SCHEMBL3041138 | 0.80 | MAPK8 (0.43) | CLK4CDK5ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8402143 | 0.79 | BTK (0.55) | — | |
| SCHEMBL6055066 | 0.78 | KDM4E (0.50) | ALDH1A1KDM4EGAAHSD17B10KMT2A | |
| SCHEMBL408618 | 0.73 | PIK3CD (0.55) | CLK4CDK5ALDH1A1KDM4ERAB9A | |
| SCHEMBL4753476 | 0.72 | CHUK (0.51) | CLK4ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL5065122 | 0.71 | PIK3CD (0.57) | CLK4CDK5ALDH1A1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020016976-A1 | Engineered protein kinases which can utilize modified nucleotide triphosphate substrates | PRINCETON UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| EP-1017823-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1998035048-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 1998-08-13 | — | — | WO | disclosed |