Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 8/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900030 | 0.74 | CDC7 (0.55) | KDM4EHSD17B10SMN1; SMN2CDC7DBF4 | |
| SCHEMBL4903144 | 0.73 | CDC7 (0.65) | KDM4EHSD17B10CDC7DBF4MAPT | |
| SCHEMBL4903044 | 0.68 | MAPT (0.70) | KDM4EHSD17B10SMN1; SMN2CDC7DBF4 | |
| SCHEMBL4899947 | 0.61 | IKBKB (0.71) | KDM4ESMN1; SMN2CDC7DBF4MAPT | |
| SCHEMBL4905123 | 0.61 | CDC7 (0.73) | KDM4EHSD17B10CDC7DBF4MAPT | |
| SCHEMBL1695176 | 0.60 | KDM4E (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL4892520 | 0.60 | LIMK1 (0.72) | KDM4EHSD17B10SMN1; SMN2CDC7DBF4 | |
| SCHEMBL5592987 | 0.59 | NOS3 (0.36) | KDM4EALDH1A1HPGD | |
| SCHEMBL4902497 | 0.57 | MEN1 (0.53) | KDM4EHSD17B10SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4903289 | 0.57 | MAPT (0.74) | KDM4EHSD17B10SMN1; SMN2CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673374-A2 | SUBSTITUTED TRICYCLIC HETEROCYCLES AND THEIR USES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035537-A2 | SUBSTITUTED TRICYCLIC HETEROCYCLES AND THEIR USES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |