Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772233 | 0.97 | KDM1A (0.49) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5775529 | 0.90 | KDM1A (0.49) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5746733 | 0.86 | HTR1B (0.51) | KDM1AHTTMAPTHTR1BHPGD | |
| SCHEMBL5776994 | 0.84 | HTT (0.52) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5822008 | 0.83 | G6PD (0.48) | KDM1AHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL5749009 | 0.82 | HTR1B (0.56) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5772950 | 0.82 | G6PD (0.49) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5773781 | 0.82 | HTT (0.50) | KDM1AHTTMAPTHTR1BKDM4E | |
| SCHEMBL5770520 | 0.81 | KDM1A (0.47) | KDM1AHTTMAPTHPGDCYP2C19 | |
| SCHEMBL5777884 | 0.80 | KDM1A (0.48) | KDM1AHTTMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |