Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19766402 | 0.87 | KMO (0.39) | KMOPLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL977647 | 0.82 | PRKCI (0.50) | KMOKDM1AHDAC1HDAC6 | |
| SCHEMBL1108271 | 0.82 | IDO1 (0.48) | KMOPLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL1467440 | 0.79 | DYRK1A (0.44) | KMOPLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL1466773 | 0.79 | CDK8 (0.46) | KMOPLK1DYRK1ADYRK1BABL1 | |
| SCHEMBL29607278 | 0.79 | CDK8 (0.46) | KMOPLK1DYRK1ADYRK1BABL1 | |
| SCHEMBL15087879 | 0.78 | DYRK1A (0.44) | KMOPLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL3023148 | 0.78 | MMP3 (0.47) | KMOPLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL1468365 | 0.78 | SLC2A4 (0.50) | PLK1DYRK1ACLK4DYRK1BCLK1 | |
| SCHEMBL1467441 | 0.77 | KARS1 (0.46) | KMOPLK1DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701944-A2 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066139-A2 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-07-21 | — | — | WO | disclosed |