Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 10/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574795 | 0.85 | BRAF (0.39) | EGFRBRAFNLRP3HTR1AHTR7 | |
| SCHEMBL575001 | 0.84 | NR3C1 (0.35) | BRAFHTR1AHTR7DRD2HTR6 | |
| SCHEMBL15191945 | 0.83 | BRAF (0.47) | BRAFMAPK3MAPK1EIF2AK3NR1I2 | |
| SCHEMBL575019 | 0.78 | KDM1A (0.37) | KDM1AEGFRBRAFMAPK3MAPK1 | |
| SCHEMBL574941 | 0.77 | BRAF (0.50) | EGFRBRAFEIF2AK3HTR1AHTR7 | |
| SCHEMBL574977 | 0.76 | BRAF (0.46) | EGFRBRAFMAPK3MAPK1EIF2AK3 | |
| SCHEMBL15191705 | 0.75 | BRAF (0.50) | EGFRBRAFMAPK3MAPK1EIF2AK3 | |
| SCHEMBL574802 | 0.75 | EIF2AK3 (0.47) | EGFRBRAFEIF2AK3NLRP3NR1I2 | |
| SCHEMBL574552 | 0.74 | BRAF (0.48) | EGFRBRAFEIF2AK3HTR1AHTR7 | |
| SCHEMBL574875 | 0.73 | BRAF (0.55) | EGFRBRAFEIF2AK3NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |