Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575020 | 0.85 | KDM1A (0.37) | BRAFEGFRHTR1AHTR7NR1I2 | |
| SCHEMBL575024 | 0.82 | CYP4F2 (0.39) | HTR1AHTR7DRD2HTR6ATR | |
| SCHEMBL575001 | 0.82 | NR3C1 (0.35) | BRAFHTR1AHTR7DRD2HTR6 | |
| SCHEMBL574769 | 0.79 | BRAF (0.38) | BRAFEGFRATR | |
| SCHEMBL15191648 | 0.79 | BRAF (0.46) | BRAFHTR1AHTR7NR1I2PIK3CA | |
| SCHEMBL574977 | 0.72 | BRAF (0.46) | BRAFEGFRNR1I2PIK3CAMTOR | |
| SCHEMBL574941 | 0.71 | BRAF (0.50) | BRAFEGFRHTR1AHTR7NR1I2 | |
| SCHEMBL17146531 | 0.71 | BRAF (0.36) | BRAF | |
| SCHEMBL574787 | 0.71 | BRAF (0.35) | BRAF | |
| SCHEMBL15191754 | 0.71 | BRAF (0.38) | BRAFATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |