Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933560 | 0.82 | KCNA3 (0.59) | KCNA3KDM4ERAB9ATP53MAPK1 | |
| SCHEMBL28498709 | 0.81 | KCNA3 (0.62) | KCNA3MEN1KMT2AMAPTTTR | |
| SCHEMBL5747505 | 0.80 | KCNA3 (0.57) | KCNA3HTR1BKDM4ETP53TDP1 | |
| SCHEMBL28851017 | 0.78 | KCNA3 (0.58) | KCNA3MEN1KMT2AMAPTTTR | |
| SCHEMBL5749560 | 0.78 | KCNA3 (0.55) | KCNA3HTR1BKDM4ERAB9AMAPK1 | |
| SCHEMBL10936005 | 0.78 | KCNA3 (0.62) | KCNA3KDM4ERAB9AMAPK1TDP1 | |
| SCHEMBL5747876 | 0.78 | KCNA3 (0.55) | KCNA3HTR1BKDM4EALDH1A1TTR | |
| SCHEMBL28986871 | 0.77 | KCNA3 (0.70) | KCNA3KDM4ERAB9AMAPK1TDP1 | |
| SCHEMBL28605135 | 0.77 | KCNA3 (0.70) | KCNA3KDM4ERAB9AMAPK1TDP1 | |
| SCHEMBL15859640 | 0.77 | KCNA3 (0.70) | KCNA3KDM4ERAB9AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |