Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747505 | 0.95 | KCNA3 (0.57) | KCNA3KDM4EHTR1BHTR1DTDP1 | |
| SCHEMBL5748969 | 0.85 | ADRB2 (0.58) | KCNA3KDM4EHTR1BALDH1A1MAPT | |
| SCHEMBL5749245 | 0.84 | HTR1B (0.56) | KCNA3KDM4EHTR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL5747876 | 0.84 | KCNA3 (0.55) | KCNA3KDM4EHTR1BALDH1A1GAA | |
| SCHEMBL7933560 | 0.80 | KCNA3 (0.59) | KCNA3KDM4ETDP1LMNAALDH1A1 | |
| SCHEMBL11605558 | 0.79 | KCNA3 (0.59) | KCNA3KDM4EHTR1BTDP1ALDH1A1 | |
| SCHEMBL28498709 | 0.79 | KCNA3 (0.62) | KCNA3LMNAMAPTTTRMEN1 | |
| SCHEMBL5750330 | 0.78 | KCNA3 (0.61) | KCNA3KDM4EHTR1BTDP1LMNA | |
| SCHEMBL5745370 | 0.77 | KCNA3 (0.52) | KCNA3KDM4EHTR1BHTR1DLMNA | |
| SCHEMBL7908960 | 0.76 | HTR1B (0.69) | KDM4EHTR1BHTR1DTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |