Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HTR1B | P28222 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749560 | 0.95 | KCNA3 (0.55) | KCNA3HRH1SLC6A4KDM4EHTR1B | |
| SCHEMBL5747876 | 0.86 | KCNA3 (0.55) | KCNA3KDM4EHTR1BL3MBTL1ALDH1A1 | |
| SCHEMBL5748969 | 0.84 | ADRB2 (0.58) | KCNA3KDM4EHTR1BL3MBTL1ALDH1A1 | |
| SCHEMBL5749245 | 0.83 | HTR1B (0.56) | KCNA3KDM4EHTR1BL3MBTL1ALDH1A1 | |
| SCHEMBL28498709 | 0.81 | KCNA3 (0.62) | KCNA3LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5750330 | 0.80 | KCNA3 (0.61) | KCNA3KDM4EHTR1BLMNATDP1 | |
| SCHEMBL7933560 | 0.78 | KCNA3 (0.59) | KCNA3KDM4ELMNATDP1TP53 | |
| SCHEMBL11605558 | 0.78 | KCNA3 (0.59) | KCNA3KDM4EHTR1BTDP1L3MBTL1 | |
| SCHEMBL28851017 | 0.78 | KCNA3 (0.58) | KCNA3LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28986871 | 0.77 | KCNA3 (0.70) | KCNA3KDM4ELMNATDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |