Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.54 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748969 | 0.96 | ADRB2 (0.58) | KCNA3ADRB2HTR1BKDM4EL3MBTL1 | |
| SCHEMBL11605558 | 0.90 | KCNA3 (0.59) | KCNA3ADRB2HTR1BKDM4EL3MBTL1 | |
| SCHEMBL5749245 | 0.86 | HTR1B (0.56) | KCNA3ADRB2HTR1BKDM4EL3MBTL1 | |
| SCHEMBL5747505 | 0.86 | KCNA3 (0.57) | KCNA3HTR1BKDM4EL3MBTL1GAA | |
| SCHEMBL5749560 | 0.84 | KCNA3 (0.55) | KCNA3ADRB2HTR1BKDM4EL3MBTL1 | |
| SCHEMBL28498709 | 0.81 | KCNA3 (0.62) | KCNA3TTRPTPN1 | |
| SCHEMBL28851017 | 0.78 | KCNA3 (0.58) | KCNA3TTRPTPN1 | |
| SCHEMBL28986871 | 0.78 | KCNA3 (0.70) | KCNA3KDM4EL3MBTL1TTRALDH1A1 | |
| SCHEMBL5750330 | 0.78 | KCNA3 (0.61) | KCNA3HTR1BKDM4ETTRALDH1A1 | |
| SCHEMBL7933560 | 0.76 | KCNA3 (0.59) | KCNA3KDM4ETTRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |