Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926526 | 0.87 | GAA (0.56) | GAAMAPTHRH3AURKAABL1 | |
| SCHEMBL2500333 | 0.87 | GAA (0.68) | GAAMAPTHRH3ALDH1A1MEN1 | |
| SCHEMBL15641708 | 0.85 | SMN1; SMN2 (0.54) | GAAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL1120384 | 0.84 | GAA (0.49) | GAAMAPTHRH3AURKAABL1 | |
| SCHEMBL1711015 | 0.84 | MAPT (0.53) | GAAMAPTHRH3AURKAABL1 | |
| Hydrochloric Acid SCHEMBL119951 | 0.83 | GAA (0.48) | GAAMAPTAURKAABL1NTRK1 | |
| SCHEMBL265097 | 0.81 | MAPT (0.50) | GAAMAPTHRH3AURKAABL1 | |
| SCHEMBL18772798 | 0.80 | SMN1; SMN2 (0.49) | GAAHRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL5534209 | 0.79 | ALDH1A1 (0.71) | MAPTHRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL12140714 | 0.77 | GAA (0.58) | GAAMAPTHRH3ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581374-B1 | Preparation of tetrahydropyrido[4,3-b]indole derivatives | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-03-19 | — | — | EP | claimed |
| EP-2581374-A1 | Preparation of tetrahydropyrido[4,3-b]indole derivatives | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2013-04-17 | — | — | EP | claimed |
| US-20120122914-A1 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A.CHINA (CN) | 2012-05-17 | — | — | US | claimed |
| EP-2417973-A1 | SUSTAINED RELEASE COMPOSITION CONTAINING TETRAHYDROPYRIDO Ý4, 3-b¨INDOLE DERIVATIVE AND PREPARATION METHOD OF DERIVATIVE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2012-02-15 | — | — | EP | claimed |
| CN-103145707-B | The preparation method of hydrogenated pyridine [4,3-b] Benzazole compounds | Institute of Toxicology and Drugs, Chinese Academy of Military Medical Sciences (CN) | 2016-05-25 | — | — | CN | disclosed |
| US-9149467-B2 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2015-10-06 | — | — | US | disclosed |
| US-9149467-B2 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2015-10-06 | — | — | US | disclosed |
| US-9149467-B2 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2015-10-06 | — | — | US | disclosed |
| US-8703952-B2 | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates | WISTA LABORATORIES LTD. (SG) | 2014-04-22 | — | — | US | disclosed |
| US-8703952-B2 | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates | WISTA LABORATORIES LTD. (SG) | 2014-04-22 | — | — | US | disclosed |
| US-8703952-B2 | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates | WISTA LABORATORIES LTD. (SG) | 2014-04-22 | — | — | US | disclosed |
| EP-2581374-B1 | Preparation of tetrahydropyrido[4,3-b]indole derivatives | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-03-19 | — | — | EP | disclosed |
| US-20120122914-A1 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A.CHINA (CN) | 2012-05-17 | — | — | US | disclosed |
| EP-2417973-A1 | SUSTAINED RELEASE COMPOSITION CONTAINING TETRAHYDROPYRIDO Ý4, 3-b¨INDOLE DERIVATIVE AND PREPARATION METHOD OF DERIVATIVE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2012-02-15 | — | — | EP | disclosed |
| EP-2417973-A1 | SUSTAINED RELEASE COMPOSITION CONTAINING TETRAHYDROPYRIDO Ý4, 3-b¨INDOLE DERIVATIVE AND PREPARATION METHOD OF DERIVATIVE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2012-02-15 | — | — | EP | disclosed |
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. | 2011-10-06 | — | — | US | disclosed |
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. | 2011-10-06 | — | — | US | disclosed |
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. | 2011-10-06 | — | — | US | disclosed |
| WO-2010067085-A2 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-Υ-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. (SG) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010067085-A2 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-Υ-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. (SG) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122914-A1 | Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives | HTT, HTR5A, HTR3B | GAA 3762/4885MAPT 32/4885HRH3 166/4885 |
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | DDT, CYP2J2, CYP1B1 | GAA 2943/4885MAPT 3823/4885HRH3 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.