Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575038 | 0.87 | GAA (0.59) | GAAL3MBTL1TSHRSMN1; SMN2HRH3 | |
| SCHEMBL27926526 | 0.84 | GAA (0.56) | GAAL3MBTL1TSHRSMN1; SMN2HRH3 | |
| SCHEMBL3844597 | 0.83 | LTA4H (0.59) | GAAL3MBTL1MAPTALDH1A1NAMPT | |
| SCHEMBL575040 | 0.81 | GAA (1.00) | GAATSHRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1562625 | 0.78 | TSHR (0.56) | GAATSHRSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10055000 | 0.78 | L3MBTL1 (0.86) | GAAL3MBTL1F2KCNH2GRIN2B | |
| SCHEMBL248884 | 0.77 | L3MBTL1 (0.70) | L3MBTL1F2KCNH2GRIN2BMAPT | |
| SCHEMBL12140714 | 0.77 | GAA (0.58) | GAATSHRSMN1; SMN2HRH3MAPT | |
| SCHEMBL5307781 | 0.76 | LTA4H (0.69) | L3MBTL1F2KCNH2GRIN2BSMN1; SMN2 | |
| SCHEMBL20749289 | 0.75 | TSHR (0.55) | GAAGRIN2BTSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703952-B2 | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates | WISTA LABORATORIES LTD. (SG) | 2014-04-22 | — | — | US | disclosed |
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. | 2011-10-06 | — | — | US | disclosed |
| WO-2010067085-A2 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-Υ-CARBOLINE AND ANALOGUES AND INTERMEDIATES | WISTA LABORATORIES LTD. (SG) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245504-A1 | SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES | DDT, CYP2J2, CYP1B1 | GAA 2943/4885L3MBTL1 3827/4885F2 2164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.