Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752713 | 0.89 | BACE1 (0.41) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL15254539 | 0.88 | KDM4E (0.39) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL5750747 | 0.85 | BACE1 (0.38) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL5754594 | 0.83 | BACE1 (0.39) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL5751776 | 0.83 | KDM4E (0.36) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL1845200 | 0.82 | MEN1 (0.35) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL21452904 | 0.81 | ATM (0.42) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL6169861 | 0.80 | ATM (0.41) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL8978512 | 0.80 | ATM (0.41) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL17929220 | 0.80 | ALDH1A1 (0.36) | KDM4ENPC1MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994871-B1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2006-02-15 | — | — | EP | claimed |
| US-5658501-A | Substituted naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | claimed |
| US-10758643-B2 | Mechanophoric medical product | AESCULAP AG (DE) | 2020-09-01 | — | — | US | disclosed |
| EP-3331581-B1 | MECHANOPHORIC MEDICAL PRODUKT | AESCULAP AG (DE) | 2020-07-08 | — | — | EP | disclosed |
| US-20190151502-A1 | Mechanophoric Medical Product | AESCULAP AG (DE) | 2019-05-23 | — | — | US | disclosed |
| EP-3331581-A1 | MECHANOPHORIC MEDICAL PRODUCT | Aesculap AG (DE) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017025408-A1 | MECHANOPHORIC MEDICAL PRODUCT | AESCULAP AG (DE) | 2017-02-16 | — | — | WO | disclosed |
| EP-0994871-B1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2006-02-15 | — | — | EP | disclosed |
| US-5658501-A | Substituted naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | disclosed |