Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553178 | 0.92 | SLC1A1 (0.59) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL5038179 | 0.88 | SLC1A3 (0.49) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL27358218 | 0.86 | L3MBTL1 (0.52) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL8668873 | 0.82 | PPARG (0.46) | PPARAPPARGPPARDALDH1A1FFAR1 | |
| SCHEMBL3643943 | 0.81 | ALDH1A1 (0.57) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL28293824 | 0.78 | PTGS2 (0.45) | CYP1A2CYP2C9CYP2C19PPARAPPARG | |
| SCHEMBL2384187 | 0.78 | SLC1A3 (0.53) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL1273202 | 0.78 | SLC1A3 (0.53) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL15528161 | 0.78 | SLC1A3 (0.53) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL20576999 | 0.77 | SLC1A2 (0.61) | KMT2ASLC1A3SLC1A2SLC1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100441579-C | Tetrahydronaphthyridine derivatives as cholesteryl ester transfer protein inhibitors | TANABE SEIYAKU CO (JP) | 2008-12-10 | — | — | CN | disclosed |
| CN-1938301-A | Tetrahydronaphthyridine derivatives as cholesteryl ester transfer protein inhibitors | TANABE SEIYAKU CO (JP) | 2007-03-28 | — | — | CN | disclosed |
| EP-1732924-A2 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095395-A2 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 2005-10-13 | — | — | WO | disclosed |