Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713063 | 0.78 | MAPT (0.54) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4713564 | 0.77 | MAPK1 (0.55) | MAPK1ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4714610 | 0.73 | MAPK1 (0.55) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8315142 | 0.70 | MAPK1 (0.52) | MAPK1ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4715672 | 0.68 | MAPT (0.65) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4715768 | 0.67 | MAPT (0.56) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4716402 | 0.67 | ALDH1A1 (0.58) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4713091 | 0.66 | ALDH1A1 (0.54) | MAPK1ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4714806 | 0.66 | MAPT (0.54) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4714178 | 0.66 | LMNA (0.57) | MAPK1MAPTNPSR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615904-A2 | SUBSTITUTED BENZOSULPHONAMIDE AS POTENTIATORS OF GLUTAMATE RECEPTORS | AstraZeneca AB (SE) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092135-A2 | SUBSTITUTED BENZOSULPHONAMIDE AS POTENTIATORS OF GLUTAMATE RECEPTORS | ASTRAZENECA (SE) | 2004-10-28 | — | — | WO | disclosed |